Background Although the peripheral and central sensitizations of trigeminal nervous system
may be one of the important factors of migraine, the precise mechanism is not fully …

Background To identify differences in allodynia and grooming behaviours between rat
models of either repeated dural nociception with inflammatory soup (IS) or infraorbital nerve …

Background: Pediatric migraine displays different clinical features from adult migraine.
Because the trigemino-vascular system (TGVS) plays a pivotal role in migraine …

Background Previous data showed that, in rats, anti‐migraine drugs (triptans, olcegepant)
significantly reduced mechanical allodynia induced by infraorbital nerve (ION) ligation but …

Background Migraine is a disabling neurological disorder, characterized by recurrent
headaches. During migraine attacks, individuals often experience sensory symptoms such …

Background Vestibular migraine has recently been recognized as a novel subtype of
migraine. However, the mechanism that relate vestibular symptoms to migraine had not …

Background Although migraine is one of the most common primary headaches, its therapy is
still limited in many cases. The use of animal models is crucial in the development of novel …

Despite the relatively high prevalence of migraine or headache, the pathophysiological
mechanisms triggering headache-associated peripheral hypersensitivities, are unknown …

Peripheral neurostimulation within the trigeminal nerve territory has been used for pain
alleviation during migraine attacks, but the mechanistic basis of this non-invasive …

Background Central sensitization is considered a critical pathogenic mechanism of chronic
migraine (CM). Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to …