TSPO ligands boost mitochondrial function and pregnenolone synthesis

I Lejri, A Grimm, F Hallé, M Abarghaz… - Journal of …, 2019 - content.iospress.com
Translocator protein 18 kDa (TSPO) is located in the mitochondrial outer membrane and
plays an important role in steroidogenesis and cell survival. In the central nervous system …

Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies

A Grimm, I Lejri, F Hallé, M Schmitt… - Journal of …, 2020 - Wiley Online Library
Translocator protein 18 kDa (TSPO) is a mitochondrial protein located in the outer
membrane and involved in cholesterol translocation, a prerequisite for steroid biosynthesis …

Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells

S Bader, L Wolf, VM Milenkovic, M Gruber… - …, 2019 - Elsevier
The translocator protein 18 kDa (TSPO), initially characterized as peripheral
benzodiazepine receptor, is a conserved outer mitochondrial membrane protein, implicated …

[HTML][HTML] 4′-Chlorodiazepam is neuroprotective against amyloid-beta in organotypic hippocampal cultures

BD Arbo, JB Hoppe, K Rodrigues… - The Journal of Steroid …, 2017 - Elsevier
The translocator protein (TSPO) is an outer mitochondrial membrane protein involved in the
transport of cholesterol into the mitochondria, which is the first step for the synthesis of …

Mitochondrial translocator protein (TSPO), astrocytes and neuroinflammation

OV Chechneva, W Deng - Neural regeneration research, 2016 - journals.lww.com
Mitochondrial translocator protein (TSPO) has been a somewhat mysterious player in
searching for its true biological functions. TSPO is involved in mitochondrial cholesterol …

Therapeutic actions of translocator protein (18 kDa) ligands in experimental models of psychiatric disorders and neurodegenerative diseases

BD Arbo, F Benetti, LM Garcia-Segura… - The Journal of steroid …, 2015 - Elsevier
Translocator protein (TSPO) is an 18 kDa protein located at contact sites between the outer
and the inner mitochondrial membrane. Numerous studies have associated TSPO with the …

TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice

A Christensen, CJ Pike - Neuroscience letters, 2018 - Elsevier
Alzheimer's disease (AD) pathogenesis is a multifactorial process that involves numerous
pathways within the central nervous system. Thus, interventions that interact with several …

Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein

A Grimm, EE Biliouris, UE Lang, J Götz… - Cellular and molecular …, 2016 - Springer
Alzheimer's disease (AD) is an age-related neurodegenerative disease marked by a
progressive cognitive decline. Metabolic impairments are common hallmarks of AD, and …

Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders

R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents

TH Kim, MN Morshed, AM Londhe, JW Lim… - Journal of enzyme …, 2021 - Taylor & Francis
Small molecule modulators of mitochondrial function have been attracted much attention in
recent years due to their potential therapeutic applications for neurodegenerative diseases …