TSPO ligands boost mitochondrial function and pregnenolone synthesis
Translocator protein 18 kDa (TSPO) is located in the mitochondrial outer membrane and
plays an important role in steroidogenesis and cell survival. In the central nervous system …
plays an important role in steroidogenesis and cell survival. In the central nervous system …
Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies
Translocator protein 18 kDa (TSPO) is a mitochondrial protein located in the outer
membrane and involved in cholesterol translocation, a prerequisite for steroid biosynthesis …
membrane and involved in cholesterol translocation, a prerequisite for steroid biosynthesis …
Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells
S Bader, L Wolf, VM Milenkovic, M Gruber… - …, 2019 - Elsevier
The translocator protein 18 kDa (TSPO), initially characterized as peripheral
benzodiazepine receptor, is a conserved outer mitochondrial membrane protein, implicated …
benzodiazepine receptor, is a conserved outer mitochondrial membrane protein, implicated …
[HTML][HTML] 4′-Chlorodiazepam is neuroprotective against amyloid-beta in organotypic hippocampal cultures
BD Arbo, JB Hoppe, K Rodrigues… - The Journal of Steroid …, 2017 - Elsevier
The translocator protein (TSPO) is an outer mitochondrial membrane protein involved in the
transport of cholesterol into the mitochondria, which is the first step for the synthesis of …
transport of cholesterol into the mitochondria, which is the first step for the synthesis of …
Mitochondrial translocator protein (TSPO), astrocytes and neuroinflammation
OV Chechneva, W Deng - Neural regeneration research, 2016 - journals.lww.com
Mitochondrial translocator protein (TSPO) has been a somewhat mysterious player in
searching for its true biological functions. TSPO is involved in mitochondrial cholesterol …
searching for its true biological functions. TSPO is involved in mitochondrial cholesterol …
Therapeutic actions of translocator protein (18 kDa) ligands in experimental models of psychiatric disorders and neurodegenerative diseases
BD Arbo, F Benetti, LM Garcia-Segura… - The Journal of steroid …, 2015 - Elsevier
Translocator protein (TSPO) is an 18 kDa protein located at contact sites between the outer
and the inner mitochondrial membrane. Numerous studies have associated TSPO with the …
and the inner mitochondrial membrane. Numerous studies have associated TSPO with the …
TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice
A Christensen, CJ Pike - Neuroscience letters, 2018 - Elsevier
Alzheimer's disease (AD) pathogenesis is a multifactorial process that involves numerous
pathways within the central nervous system. Thus, interventions that interact with several …
pathways within the central nervous system. Thus, interventions that interact with several …
Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein
Alzheimer's disease (AD) is an age-related neurodegenerative disease marked by a
progressive cognitive decline. Metabolic impairments are common hallmarks of AD, and …
progressive cognitive decline. Metabolic impairments are common hallmarks of AD, and …
Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders
R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents
TH Kim, MN Morshed, AM Londhe, JW Lim… - Journal of enzyme …, 2021 - Taylor & Francis
Small molecule modulators of mitochondrial function have been attracted much attention in
recent years due to their potential therapeutic applications for neurodegenerative diseases …
recent years due to their potential therapeutic applications for neurodegenerative diseases …