Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

T Rajaei, H Farajifard, H Rafatpanah, R Bustani… - Medical microbiology …, 2017 - Springer
Abstract Interleukin-21 (IL-21) enhances the survival and cytotoxic properties of cytotoxic T
cells (CTLs) and exhibits essential roles in controlling chronic viral infections. HTLV-1 …

How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis?

N Azimi, J Mariner, S Jacobson… - AIDS research and …, 2000 - liebertpub.com
HTLV-1 is the etiological agent of a neurological disease named HAM/TSP that has clinical
characteristics similar to those of multiple sclerosis (MS). The PBMC obtained from …

The IL-18, IL-12, and IFN-γ expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, HTLV-1 carriers, and healthy subjects

HR Bidkhori, MR Hedayati-Moghaddam… - Journal of …, 2020 - Springer
Abstract Interleukin (IL)-12, IL-18, and interferon gamma (IFN-γ) can induce Th1-
inflammatory responses in favor of HTLV-1-associated myelopathy/tropical spastic …

Role of Interleukin-17 cytokine family in human T-cell lymphotropic virus type 1 (HTLV-1) infection and associated diseases

M Shafiei, S Ghadimi, P Baharlou, F Moghimi… - Cytokine, 2024 - Elsevier
Background Human T-lymphotropic virus (HTLV-1) is a neglected virus with worldwide
distribution of over 10 million people and is the cause of two main associated diseases Adult …

[HTML][HTML] Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

LL Gois, B Ribeiro-Soares, CG Regis-Silva… - BMC Infectious …, 2024 - Springer
Background Human T-cell lymphotropic virus type 1 (HTLV-1), also denominated Human T-
cell leukemia virus-1, induces immune activation and secretion of proinflammatory …

Up-regulation of interleukin-12 receptor expression in peripheral blood mononuclear cells of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

T Fujimoto, T Nakamura, Y Nishiura, K Ichinose… - Journal of the …, 2002 - Elsevier
We previously reported elevated levels of serum interleukin-12 (IL-12) in association with
increased interferon-γ (IFN-γ) levels in patients with human T-lymphotropic virus type I …

IL17A Polymorphism Is Not Associated with Human T-Lymphotropic Virus 1-Associated Myelopathy/Tropical Spastic Paraparesis

HVPC Neco, VGS Teixeira, ACL Trindade… - Viral …, 2017 - liebertpub.com
The human T-lymphotropic virus 1 (HTLV-1) is the causative agent of HTLV-1-associated
myelopathy/tropical spastic paraparesis (HAM/TSP). The present study investigated the …

Th17/IL-17 Axis in HTLV-1-associated myelopathy tropical spastic Paraparesis and multiple sclerosis: novel insights into the immunity during HAMTSP

M Shafiei, SH Mozhgani - Molecular Neurobiology, 2023 - Springer
Human T lymphotropic virus–associated myelopathy/tropical spastic paraparesis
(HTLV/TSP), also known as HTLV-associated myelopathy/tropical spastic paraparesis …

Interferon lambda family along with HTLV-1 proviral load, tax, and HBZ implicated in the pathogenesis of myelopathy/tropical spastic paraparesis

SH Mozhgani, HR Jahantigh, H Rafatpanah… - Neurodegenerative …, 2018 - karger.com
Abstract HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic
neuroinflammatory disease related to human T lymphotropic virus type 1 (HTLV-1) infection …

[HTML][HTML] IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways

L Sawada, Y Nagano, A Hasegawa, H Kanai… - PLoS …, 2017 - journals.plos.org
Human T-cell leukemia virus type-1 (HTLV-1) causes two distinct diseases, adult T-cell
leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis …