Mitofusins are dynamin-related GTPases that drive mitochondrial fusion by sequential
events of oligomerization and GTP hydrolysis, followed by their ubiquitylation. Here, we …

Mitochondria are essential organelles whose function is upheld by their dynamic nature.
This plasticity is mediated by large dynamin-related GTPases, called mitofusins in the case …

Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power
membrane-remodeling events via self-interaction and GTP hydrolysis. However, how exactly …

Mitofusins (Mfns) are dynamin-related GTPases that mediate mitochondrial outer-membrane
fusion, a process that is required for mitochondrial and cellular health. In Mfn1 and Mfn2 …

Mitochondria are highly dynamic organelles that constantly undergo fission and fusion.
Disruption of mitochondrial dynamics undermines their function and causes several human …

Mitochondrial integrity relies on homotypic fusion between adjacent outer membranes,
which is mediated by large GTPases called mitofusins. The regulation of this process …

Mitofusins, conserved dynamin-related GTPases in the mitochondrial outer membrane,
mediate the fusion of mitochondria. Here, we demonstrate that the activity of the mitofusin …

Cdc48/p97, a ubiquitin-selective chaperone, orchestrates the function of E3 ligases and
deubiquitylases (DUBs). Here, we identify a new function of Cdc48 in ubiquitin-dependent …

Mitochondria are energy-converting organelles that shift between fusion and fission states in
order to perform a variety of essential functions. Disruption of these dynamics is detrimental …

Dynamin-related GTPase proteins (DRPs) are main players in membrane remodelling.
Conserved DRPs called mitofusins (Mfn1/Mfn2/Fzo1) mediate the fusion of mitochondrial …