Variable gene expression within a clonal population of cells has been implicated in a
number of important processes including mutation and evolution,, determination of cell fates …

Variability in gene expression among genetically identical cells has emerged as a central
preoccupation in the study of gene regulation; however, a divide exists between the …

Transcription in eukaryotic cells has been described as quantal, with pulses of messenger
RNA produced in a probabilistic manner,. This description reflects the inherently stochastic …

Clonal populations of cells exhibit substantial phenotypic variation. Such heterogeneity can
be essential for many biological processes and is conjectured to arise from stochasticity, or …

Genetic variation segregating within a species reflects the combined activities of mutation,
selection, and genetic drift. In the absence of selection, polymorphisms are expected to be a …

Noise, or random fluctuations, in gene expression may produce variability in cellular
behavior. To measure the noise intrinsic to eukaryotic gene expression, we quantified the …

For most biological processes, organisms must respond to extrinsic cues, while maintaining
essential gene expression programmes. Although studied extensively in single cells, it is still …

Gene expression responds to changes in conditions but also stochastically among
individuals. In budding yeast, both expression responsiveness across conditions …

Gene expression, like many biological processes, is subject to noise. This noise has been
measured on a global scale, but its general importance to the fitness of an organism is …

Identifying the properties of gene networks that influence their evolution is a fundamental
research goal. However, modes of evolution cannot be inferred solely from the distribution of …