Extensive transcriptional heterogeneity revealed by isoform profiling
Transcript function is determined by sequence elements arranged on an individual RNA
molecule. Variation in transcripts can affect messenger RNA stability, localization and …
molecule. Variation in transcripts can affect messenger RNA stability, localization and …
[HTML][HTML] Pathway dynamics can delineate the sources of transcriptional noise in gene expression
Single-cell expression profiling opens up new vistas on cellular processes. Extensive cell-to-
cell variability at the transcriptomic and proteomic level has been one of the stand-out …
cell variability at the transcriptomic and proteomic level has been one of the stand-out …
Pervasive coexpression of spatially proximal genes is buffered at the protein level
G Kustatscher, P Grabowski… - Molecular systems …, 2017 - embopress.org
Genes are not randomly distributed in the genome. In humans, 10% of protein‐coding genes
are transcribed from bidirectional promoters and many more are organised in larger clusters …
are transcribed from bidirectional promoters and many more are organised in larger clusters …
Revealing dynamics of gene expression variability in cell state space
D Grün - Nature methods, 2020 - nature.com
To decipher cell state transitions from single-cell transcriptomes it is crucial to quantify weak
expression of lineage-determining factors, which requires computational methods that are …
expression of lineage-determining factors, which requires computational methods that are …
[HTML][HTML] Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors
P Kemmeren, K Sameith, LAL Van De Pasch… - Cell, 2014 - cell.com
To understand regulatory systems, it would be useful to uniformly determine how different
components contribute to the expression of all other genes. We therefore monitored mRNA …
components contribute to the expression of all other genes. We therefore monitored mRNA …
Variability in gene expression underlies incomplete penetrance
The phenotypic differences between individual organisms can often be ascribed to
underlying genetic and environmental variation. However, even genetically identical …
underlying genetic and environmental variation. However, even genetically identical …
Positive selection for elevated gene expression noise in yeast
It is well known that the expression noise is lessened by natural selection for genes that are
important for cell growth or are sensitive to dosage. In theory, expression noise can also be …
important for cell growth or are sensitive to dosage. In theory, expression noise can also be …
Identifying single-cell molecular programs by stochastic profiling
Cells in tissues can be morphologically indistinguishable yet show molecular expression
patterns that are remarkably heterogeneous. Here we describe an approach to …
patterns that are remarkably heterogeneous. Here we describe an approach to …
[HTML][HTML] Fitness effects of altering gene expression noise in Saccharomyces cerevisiae
Gene expression noise is an evolvable property of biological systems that describes
differences in expression among genetically identical cells in the same environment. Prior …
differences in expression among genetically identical cells in the same environment. Prior …
Stochasticity in gene expression: from theories to phenotypes
Genetically identical cells exposed to the same environmental conditions can show
significant variation in molecular content and marked differences in phenotypic …
significant variation in molecular content and marked differences in phenotypic …