Dopamine-derived 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (salsolinol, Sal)
and related compounds were examined for their selective neurotoxicity to dopamine …

The study was carried out on the lumbar cerebrospinal fluid (CSF) samples taken from
nonparkinsonian, early parkinsonian, and advanced parkinsonian patients. Some patients …

Using a solid-phase extraction procedure and a gas chromatographic–mass spectrometric
(GC/MS) method the levels of dopamine and the levels of dopamine-derived salsolinol …

Urinary salsolinol output had been shown to be lower in Parkinsonian patients than in
controls and to increase largely after L-dopa therapy. It had also been established that the R …

Salidroside has been identified as one of the most potent compounds isolated from various
Rhodiola plants, which have been used for a long time as adaptogens in traditional Chinese …

Tetrahydroisoquinolines present in the mammalian brain, 1, 2, 3, 4-tetrahydroisoquinoline
(TIQ) and salsolinol, suspected to cause neurodegeneration leading to Parkinson's disease …

Catecholamines and aldehydes are known to undergo a Pictet-Spengler type condensation
to form tetrahydroisoquinolines [11. One of the most extensively studied condensation …

A sensitive, specific, and robust method to simultaneously determine enantiomeric salsolinol
(1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline, SAL), a potential biomarker …

The contribution of (R)-enantiomer of N-methyl-salsolinol (1, 2-dimethyl-6, 7-dihydroxy-1, 2,
3, 4-tetrahydroisoquinoline; NMSal) to the degeneration of dopaminergic neurons in the …

The endogenous neurotoxin, 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline
(salsolinol), has been considered a potential neurotoxin in the etiology of Parkinson's …