Parkinson's disease is associated with degeneration of dopaminergic cell bodies in the
substantia nigra. It has been suggested that salsolinol, an endogenous metabolite of …

Parkinson's disease (PD) arises from the loss of dopaminergic neurons in the substantia
nigra. 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is well known to cause …

Summary 1 (R), 2 (N)-Dimethyl-6, 7-dihydroxy-l, 2, 3, 4-tetrahydroisoquinoline, N-methyl (R)
salsolinol, is a potent dopaminergic neurotoxin to induce parkinsonism in rats. The …

The tetrahydroisoquinoline alkaloids salsolinol and norsalsolinol were found in human urine
samples in concentrations ranging from 0.1 to 29.5 ng/ml. Great interindividual variation was …

Salsolinol (SAL), a novel dopaminergic catechol tetrahydroisoquinoline neurotoxin, has
been speculated to contribute to the etiology of Parkinson's disease and neuropathology of …

Utilizing a simulated gastrointestinal medium which approximates physiological conditions
within the mammalian GI tract, experiments aimed at isolating and identifying unique …

We could quantify the tetrahydroisoquinoline derivative salsolinol in urine of patients with
Parkinson's disease and normal control subjects by means of high performance liquid …

Endogenously synthesised norsalsolinol derivatives are elevated in Parkinson's disease
(PD) and have been considered potentially useful biological markers of the disease …

The effects of derivatives of dopamine‐derived isoquinoline,(R)‐1‐methyl‐6, 7‐dihydroxy‐1,
2, 3, 4‐tetrahydroisoquinoline [or (R)‐salsolinol] on hydroxyl radical production were studied …

Recently,(R)-1, 2-dimethyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline [N-methyl-(R)
salsolinol, NM (R) Sal] and 1, 2-dimethyl-6, 7-dihydroxyisoquinolinium ion [DiMeDHIQ+] …