Aims: The in vivo formation of salsolinol (1-methyl-6, 7-dihydroxy-1, 2, 3, 4-
tetrahydroisoquionoline), an endogeneous condensation product of dopamine (DA) with …

An endogenous neurotoxin, N-methyl (R) salsolinol, has been proved to be involved in the
pathogenesis of Parkinson's disease. Increased level of N-methyl (R) salsolinol in the …

Dopamine (DA) condenses, at least in vitro, with acetaldehyde, the primary metabolite of
ethanol, to form the regioisomers salsolinol (SAL) and isosalsolinol (isoSAL). An alternative …

Safinamide (Xadago) is a novel dual-mechanism drug that has been approved in the
European Union and United States as add-on treatment to levodopa in Parkinson's disease …

Abstract Parkinson's disease (PD), a progressive neurodegenerative disorder, is associated
with the destruction of dopamine neurons in the substantia nigra (SN) and the formation of …

N-Methylsalsolinol, an analogue of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine, is
present in the brains of patients with Parkinson's disease. To determine the metabolic …

Rationale Microinjections of ethanol and acetaldehyde into ventral tegmental area (VTA)
produce locomotor activation in rats through mechanisms dependent on the μ-opioid …

Although the etiology of Parkinson's disease (PD) remains elusive, a number of toxins
including elevated salsolinol, an endogenous metabolite of dopamine may contribute to its …

Background: Dopamine (DA)‐derived tetrahydroisoquinolines (TIQs) are discussed as
neurochemical factors of addiction processes in alcoholism. In a prospective study, the …

The enantiomers of salsolinol were completely separated as diastereoisomeric derivatives,
after reaction with S-1-(1-naphthyl) ethyl isothiocyanate, by reversed-phase high …