Metabolites are the small biological molecules involved in energy conversion and
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …

High-resolution mass spectrometry (MS) has advanced the study of metabolism in living
systems by allowing many metabolites to be measured in a single experiment. Although …

Highlights•Metabolomics provides a functional read-out of the physiological status of an
organism.•A precise (dynamic) description of the clinical phenotype is missing for complex …

Metabolite identification represents a major challenge, and opportunity, for biochemistry.
The collective characterization and quantification of metabolites in living organisms, with its …

Metabolomics studies rely on the analysis of the multitude of small molecules (metabolites)
present in a biological system. Most commonly, metabolomics is heavily supported by mass …

Untargeted metabolomics aims to quantify the complete set of metabolites within a biological
system, most commonly by liquid chromatography/mass spectrometry (LC/MS). Since nearly …

Metabolomics analysis generates vast arrays of data, necessitating comprehensive
workflows involving expertise in analytics, biochemistry and bioinformatics in order to …

Metabolomics is the study of the metabolome, the collection of small molecules in living
organisms, cells, tissues, and biofluids. Technological advances in mass spectrometry …

Metabolomics aims at detection and quantitation of all metabolites in biological samples.
The presence of metabolites with a wide variety of physicochemical properties and different …

Metabolites are building blocks of cellular function. These species are involved in enzyme-
catalyzed chemical reactions and are essential for cellular function. Upstream biological …