A considerable number of fungal homologues of human apoptotic genes have been
identified in recent years. Nevertheless, we are far from being able to connect the different …

Programmed cell death (PCD) pathways are found in many phyla, ranging from
developmentally programmed apoptosis in animals to cell-autonomous programmed …

Wild-type strains of the ascomycete Podospora anserina are characterized by a limited
lifespan. Mitochondria play a central role in this ageing process raising the question of …

How the host cells of plants and animals protect themselves against fungal invasion is a
biologically interesting and economically important problem. Here we investigate the …

Transcription factor IIH (TFIIH) participates in transcription, nucleotide excision repair and
the control of the cell cycle. In the present study, we demonstrate that the Dmp52 subunit of …

Living organisms have to protect the integrity of their genomes in order to survive. A
mechanism called the DNA damage response was developed during evolution to ensure …

Wild-type filamentous fungus Neurospora crassa continues to grow its hyphae for a very
lengthy period of time (> 2 years), whereas mutations at the natural death (nd) locus shorten …

Programmed cell death (PCD) in filamentous fungi prevents cytoplasmic mixing following
fusion between conspecific genetically distinct individuals (allorecognition) and serves as a …

Cell survival has been closely linked to both trophic growth factor signaling and cellular
metabolism. Such couplings have obvious physiologic and pathophysiologic implications …

We have studied the effects of phytosphingosine (PHS) on cells of the filamentous fungus
Neurospora crassa. Highly reduced viability, impairment of asexual spore germination, DNA …