2498 MARON BA et al. tion of eNOS is dynamically regulated9 and the enzyme is thus
exposed to different concentrations of ROS depending upon where in the cell the protein is …

Endothelial nitric oxide synthase (eNOS) is regulated by multiple mechanisms including
Ca2+/calmodulin binding, protein-protein interactions, phosphorylation, and subcellular …

In 1980, Furchgott and Zawadzki demonstrated that the relaxation of vascular smooth
muscle cells in response to acetylcholine is dependent on the anatomical integrity of the …

The complex regulation of eNOS (endothelial nitric oxide synthase) in cardiovascular
physiology occurs at multiple stages. eNOS mRNA levels are controlled both at the …

The objective of this study was to determine whether absence of endothelial nitric oxide
synthase (eNOS) affects the expression of cell surface adhesion molecules in endothelial …

This article explores the physiology of superoxide generation by endothelial nitric oxide
synthase (eNOS), the so-called “uncoupled” state of the enzyme. The fact that this alternative …

Endothelium-derived nitric oxide (NO) is a key determinant of blood pressure homeostasis
and platelet aggregation and is synthesized by the endothelial isoform of nitric oxide …

Impaired nitric oxide (NO) activity in proatherosclerotic states has been suggested to be
caused mainly by increased degradation of NO by oxygen radicals. In recent years …

Endothelial NOS (eNOS), and its product NO, are vital components of the control of
vasomotor function and cardiovascular homeostasis. In the present review, we will take a …

The endothelial isoform of nitric-oxide synthase (eNOS) undergoes a complex pattern of
covalent modifications, including acylation with the fatty acids myristate and palmitate as …