Metformin suppresses foam cell formation, inflammation and ferroptosis via the AMPK/ERK signaling pathway in ox‑LDL‑induced THP‑1 monocytes

Y Zhao, Y Zhao, Y Tian, Y Zhou - Experimental and …, 2022 - spandidos-publications.com
Numerous studies have shown that the formation of foam cells is of vital importance in the
process of atherosclerosis. The aim of the present study was to assess the effects of …

Metformin ameliorates Ox-LDL-induced foam cell formation in raw264. 7 cells by promoting ABCG-1 mediated cholesterol efflux

X He, X Chen, L Wang, W Wang, Q Liang, L Yi, Y Wang… - Life sciences, 2019 - Elsevier
Aims The accumulation of lipids in macrophages contributes to the development of
atherosclerosis. Cholesterol efflux of lipid-loaded macrophages mediated by ATP binding …

[HTML][HTML] Inhibitory effects of resveratrol on foam cell formation are mediated through monocyte chemotactic protein-1 and lipid metabolism-related proteins

W Dong, X Wang, S Bi, Z Pan… - International …, 2014 - spandidos-publications.com
Resveratrol has been shown to exert anti-atherosclerotic effects. 5'AMP-activated protein
kinase (AMPK) and monocyte chemotactic protein-1 (MCP-1) play key roles in foam cell …

[HTML][HTML] GABA and topiramate inhibit the formation of human macrophage-derived foam cells by modulating cholesterol-metabolism-associated molecules

Y Yang, YT Lian, SY Huang, Y Yang… - Cellular Physiology and …, 2014 - karger.com
Aims: γ-aminobutyric acid (GABA), the principal inhibitory neurotransmitter, acts on GABA
receptors to play an important role in the modulation of macrophage functions. The present …

Atorvastatin enhances foam cell lipophagy and promotes cholesterol efflux through the AMP-activated protein kinase/mammalian target of rapamycin pathway

S Zheng, Y Du, Q Ye, K Zha, J Feng - Journal of cardiovascular …, 2021 - journals.lww.com
Foam cells are the main pathological components of atherosclerosis. Therapies reducing
foam cell formation can effectively prevent atherosclerotic diseases and cardiovascular …

[HTML][HTML] Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPARγ-ABCA1 pathway

L Sun, E Li, F Wang, T Wang, Z Qin… - International journal of …, 2015 - ncbi.nlm.nih.gov
The accumulation of cholesterol in macrophages could induce the formation of foam cells
and increase the risk of developing atherosclerosis. We wonder if quercetin, one of …

[HTML][HTML] Salidroside protects against foam cell formation and apoptosis, possibly via the MAPK and AKT signaling pathways

J Ni, Y Li, W Li, R Guo - Lipids in health and disease, 2017 - Springer
Background Foam cell formation and apoptosis are closely associated with atherosclerosis
pathogenesis. We determined the effect of salidroside on oxidized low-density lipoprotein …

[HTML][HTML] Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway

S Franceschelli, F De Cecco, M Pesce, P Ripari… - International journal of …, 2023 - mdpi.com
Cholesterol accumulation in macrophages leads to the formation of foam cells and
increases the risk of developing atherosclerosis. We have verified whether hydroxytyrosol …

Berberine attenuates cholesterol accumulation in macrophage foam cells by suppressing AP-1 activity and activation of the Nrf2/HO-1 pathway

XJ Yang, F Liu, N Feng, XS Ding, Y Chen… - Journal of …, 2020 - journals.lww.com
Atherosclerosis is a chronic inflammation condition resulting from the interaction between
lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in …

EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1

JY Tsai, KH Su, SK Shyue, YR Kou, YB Yu… - Cardiovascular …, 2010 - academic.oup.com
Aims Accumulation of foam cells in the intima is a hallmark of early-stage atherosclerotic
lesions. Ginkgo biloba extract (EGb761) has been reported to exert anti-oxidative and anti …