Elevated saturated free fatty acid levels during over-nutrition lead to hypothalamic
inflammation, which perturbs energy homeostasis. Whether brain-derived metabolites are …

Nutrient composition in obesogenic diets may influence the severity of disorders associated
with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that …

The brain is rich in lipid and fatty molecules. In this review article, we focus on fatty acid
binding proteins (Fabps) that bind to fatty acids such as arachidonic acid and …

Nutrient-sensitive neurons [to glucose and fatty acids (FAs)] are present at many sites
throughout the brain, including the hypothalamus and brain stem, and play a key role in the …

In mammals, brain function, particularly neuronal activity, has high energy needs. When
glucose is supplemented by alternative oxidative substrates under different physiological …

Obesity is linked to increased risk of Alzheimer's disease and cognitive impairment.
Microglia-mediated neuroinflammation is implicated in neuronal loss. Elevated levels of fatty …

The degree to which fatty acids modulate brain function beyond periods of rapid brain
growth is poorly understood. Nevertheless, recent evidence suggests that dietary fatty acid …

The number of people diagnosed with metabolic syndrome (MetS) has increased
dramatically to reach alarming proportions worldwide. The origin of MetS derives from bad …

Obesity is associated with cognitive impairments. Long-term mechanisms for this association
include consequences of hyperglycemia, dyslipidemia, or other factors comprising metabolic …

Obesity is a health problem that involves fat accumulation in adipose and other tissues and
causes cell dysfunction. Long-chain saturated fatty acids can induce and propagate …