For nearly 100 years, developmental biologists have utilized fate mapping to understand the
contributions of progenitor populations to organogenesis. More recently, Cre-Lox technology …

A kidney is an organ with relatively low basal cellular regenerative potential. However, renal
cells have a pronounced ability to proliferate after injury, which undermines that the kidney …

Recent studies have identified a poorly appreciated yet extensive population of perivascular
mesenchymal cells in the kidney, which are derived from metanephric mesenchyme …

Terminally differentiated cells can be reprogrammed to pluripotency or directly to another
differentiated cell type in vitro, a capacity termed cellular plasticity. Plasticity is not limited to …

Understanding the mechanisms of nephron repair is critical for the design of new therapeutic
approaches to treat kidney disease. The kidney can repair after even a severe insult, but …

The ability of the human kidney to repair itself is limited. Consequently, repeated injury can
trigger a maladaptive response that is characterized by fibrosis and loss of renal function …

The mammalian kidney is a highly complex organ that requires the precise structural
arrangement of multiple cell types for effective function. The need to filter large volumes of …

Within the developing mammalian kidney, several populations of progenitors form the
discrete cellular components of the final organ. Fate mapping experiments revealed the cap …

The increasing prevalence of chronic kidney disease in the absence of new treatment
modalities has become a strong driver for innovation in nephrology. An increasing …

The mechanism and magnitude by which the mammalian kidney generates and maintains
its proximal tubules, distal tubules, and collecting ducts remain controversial. Here, we use …