Bone metastases are associated with a broad spectrum of clinical sequelae. Pain, reduced
mobility, skeletal complications and treatment-related events reduce quality of life …

Bone metastases from advanced stage cancers are common. They pose a significant added
burden on both the patient and the health care system as a whole. There has been …

Introduction: Current treatment for metastatic bone pain is mainly palliative. Recent insights
into the molecular mechanisms involved in bone metastases have led to the identification of …

The principal objective for any medical therapy is to improve either the duration of life and/or
its quality. Metastases in bone can lead to clinically defined events termed skeletal-related …

Bone metastases are a frequent complication of solid tumors, leading to significant skeletal
sequelae that negatively impact quality of life and survival. Prevention and management of …

All bone surfaces are periodically remodeled by the coupled and balanced action of
osteoclasts and osteoblasts, of which the activities are regulated by a variety of cytokines …

Abstract Objective Skeletal related events (SREs) are common in patients with bone
metastases and lead to decreased quality of life and functional status. The definition of an …

Bone metastasis is one of the most important factors associated with poor prognosis for
patients with prostate, breast, thyroid, and lung cancer. In the past two decades, 651 clinical …

Highlights•Increased incidence of bone metastases requires adapted therapeutic
strategies.•Therapeutic objectives: relieve severe pain and improve the functional …

Bone metastases contribute to a significant degree of morbidity in patients with common
cancers through the development of skeletal related events (SRE) such as bone pain and …