Total synthesis of the originally proposed chrysamide B (2) is described, which features a
convergent assembly of the chiral piperazine core and epoxy-acid. Mismatched …

We report an efficient synthesis of the dimeric trans-epoxyamide chrysamide B, recently
isolated from the deep-sea-derived fungus Penicillium chrysogenum SCSIO41001. Our …

Tuberculosis (TB) is a life-threatening disease resulting in an estimated 10 million new
infections and 1.8 million deaths annually, primarily in underdeveloped countries. The …

The first regioselective syntheses of 6-(1, 1-dimethylallyl)-and 8-(3, 3-dimethylallyl) chrysins
have been designed. Claisen rearrangement of protected 5-O-(3, 3-dimethylallyl) chrysin in …

Anthraquinone and its derivatives show remarkable biological properties such as
anticancer, antibacterial, antifungal, and antiviral activities. Hence, anthraquinones …

Some new derivatives of natural chrysin have been synthesized and evaluated for
antibacterial, antibiofilm and antifungal activities. Three compounds, namely 2a, 2e, 2i …

In order to search for drugs with excellent antibacterial activities, a series of novel chrysin
derivatives were designed, synthesized, and evaluated as antibacterial agents. Results of …

Several N‐arylpiperazine phosphoramide analogues of chrysin are synthesized through a
facile phosphorylated reaction for the first time. Their structures are elucidated by NMR, ESI …

As a naturally wide distributed flavone, chrysin exhibits numerous biological activities
including anticancer, anti-inflammatory, and antimicrobials activities. β-Ketoacyl-acyl carrier …

Chrysin is a widely distributed natural flavonoid with broad biological activities, but its poor
bioavailability and insufficient efficacy limit its clinical applications. Based on prodrug and …