Most severe forms of intellectual disability (ID) have specific genetic causes. Numerous X
chromosome gene defects and disease-causing copy-number variants have been linked to …

In the last few years, next-generation sequencing has led to enormous progress in
deciphering monogenic forms of intellectual disability. Autosomal dominant intellectual …

Autosomal recessive (AR) gene defects are the leading genetic cause of intellectual
disability (ID) in countries with frequent parental consanguinity, which account for about …

Early onset intellectual disability (ID) is one of the largest unsolved problems of health care.
Yet, it has received very little public attention in the past because many health care …

Intellectual disability (ID) occurs in almost 3% of newborns. Despite substantial research, a
fundamental question about its origin and links to intelligence (IQ) still remains. ID has been …

The genetics of autosomal recessive intellectual disability (ARID) has mainly been studied in
consanguineous families, however, founder populations may also be of interest to study …

In the past decade, we have witnessed a flood of reports about mutations that cause or
contribute to intellectual disability (ID). This rapid progress has been driven in large part by …

In outbred Western populations, most individuals with intellectual disability (ID) are sporadic
cases, dominant de novo mutations (DNM) are frequent, and autosomal recessive ID (ARID) …

Intellectual disability (ID) is a clinically and genetically heterogeneous disorder, affecting 1–
3% of the general population. Although research into the genetic causes of ID has recently …

Intellectual disability (ID) is the leading socio-economic problem of health care, but
compared to autism and schizophrenia, it has received very little public attention. Important …