Soil-transmitted helminthic vaccines: Where are we now?

MTJ Wong, NS Anuar, R Noordin, GJ Tye - Acta tropica, 2023 - Elsevier
It has been tested and proven that vaccination is still the best strategy to combat infectious
diseases. However, to date, there are still no vaccines against human soil-transmitted …

Soil-transmitted helminth vaccines: are we getting closer?

A Zawawi, KJ Else - Frontiers in immunology, 2020 - frontiersin.org
Parasitic helminths infect over one-fourth of the human population resulting in significant
morbidity, and in some cases, death in endemic countries. Despite mass drug administration …

The yin and yang of human soil-transmitted helminth infections

A Loukas, RM Maizels, PJ Hotez - International journal for parasitology, 2021 - Elsevier
The major soil-transmitted helminths that infect humans are the roundworms, whipworms
and hookworms. Soil-transmitted helminth infections rank among the most important …

Recombinant subunit vaccines for soil-transmitted helminths

JB Noon, RV Aroian - Parasitology, 2017 - cambridge.org
Soil-transmitted helminths (STHs) collectively infect one fourth of all human beings, and the
majority of livestock in the developing world. These gastrointestinal nematodes are the most …

Promising technologies in the field of helminth vaccines

DJ Perera, M Ndao - Frontiers in immunology, 2021 - frontiersin.org
Helminths contribute a larger global burden of disease than both malaria and tuberculosis.
These eukaryotes have caused human infections since before our earliest recorded history …

Advances in helminth immunology: optimism for future vaccine design?

NL Harris - Trends in parasitology, 2011 - cell.com
Intestinal helminths infect approximately 2 billion people worldwide. Worm burdens correlate
with disease morbidity and children generally harbor the largest numbers. The majority of …

Identifying novel candidates and configurations for human helminth vaccines

RM Maizels - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction: Human infections with helminth worm parasites are extraordinarily prevalent
across tropical and subtropical parts of the world, and control relies primarily on drugs that …

Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative

PJ Hotez, B Zhan, JM Bethony, A Loukas… - International journal for …, 2003 - Elsevier
Hookworm infection is one of the most important parasitic infections of humans, possibly
outranked only by malaria as a cause of misery and suffering. An estimated 1.2 billion …

Human anthelminthic vaccines: Rationale and challenges

PJ Hotez, U Strych, S Lustigman, ME Bottazzi - Vaccine, 2016 - Elsevier
Helminth infections are the most common afflictions of humankind, affecting almost every
single person living in profound poverty. Through mass drug administration (MDA) we have …

Vaccination against helminth parasite infections

JP Hewitson, RM Maizels - Expert review of vaccines, 2014 - Taylor & Francis
Helminth parasites infect over one fourth of the human population and are highly prevalent
in livestock worldwide. In model systems, parasites are strongly immunomodulatory, but the …