As healthcare systems are improving and thereby the life expectancy of human populations
is increasing, cancer is representing itself as the second leading cause of death. Although …

Cancer is composed of a major subpopulation of proliferative cells and a minor
subpopulation of highly adaptable cells. Although it is evident that cancer is an evolution like …

Drug resistance remains a major problem in the treatment of most cancers. For example,
KRAS wild-type colorectal cancers (CRCs) are typically treated with the anti-epidermal …

Background Disseminated cancer remains a nearly uniformly fatal disease. While a number
of effective chemotherapies are available, tumors inevitably evolve resistance to these drugs …

Colorectal cancer (CRC) ranks among the most prevalent cancers and contributes
significantly to cancer-related fatalities. Chemoresistance in CRC poses a considerable …

Colorectal cancer (CRC) is one of the most prevalent cancers and the second leading cause
of cancer mortality worldwide. Survival in the metastatic setting has been gradually improved …

Colorectal cancer (CRC) remains the third most common cause of cancer-related deaths in
both men and women worldwide. Despite recent advances in clinical practice and effective …

The ever-changing nature of cancer poses the most difficult challenge oncologists face
today. Cancer's remarkable adaptability has inspired many to work toward understanding …

Genomic instability and a high mutation rate lead to heterogeneity in human tumors.
Mathematical modelling predicts that these characteristics promote acquired resistance to …

The widespread use of next generation sequencing (NGS) has led to a refined
understanding of the genomics of colorectal cancer (CRC). However, progress in the use of …