Carcinogenesis is an evolutionary process that establishes the 'hallmarks of cancer'by
natural selection of cell clones that have acquired advantageous heritable characteristics …

Resistance to chemotherapy limits the effectiveness of current cancer therapies, including
those used to treat colorectal cancer, which is the second most common cause of cancer …

Multi-modal treatment of non-metastatic locally advanced rectal adenocarcinoma (LARC)
includes chemotherapy, radiation, and life-altering surgery. Although highly effective for …

Twenty million people around the world are diagnosed with cancer every year and over ten
million people die because their cancer has metastasized and is incurable using current …

Cancer therapy resistance still poses the biggest hurdle to cancer treatment. In everyday
clinical practice, oncologists face resistance to numerous cancer therapies, resulting in …

Cancer patients die primarily due to disease recurrence after transient treatment responses.
The emergence of therapy‐resistant escape variants is fuelled by intra‐tumour …

New applications of evolutionary biology are transforming our understanding of cancer. The
articles in this special issue provide many specific examples, such as microorganisms …

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies,
Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal …

The cancer burden continues to grow globally, and drug resistance remains a substantial
challenge in cancer therapy. It is well established that cancerous cells with clonal dysplasia …

Chemotherapy is the standard treatment for many, if not all, metastatic cancers. While
chemotherapy is often capable of inducing cell death in tumors leading to shrinkage of the …