During the past years, molecular studies through high-throughput technologies have led to
the confirmation of critical alterations in colorectal cancer (CRC) and the discovery of some …

Many biological systems are resilient to shock and have the ability to return to a previous
state following a disturbance. In the case of cancer, this resilience may jeopardize our …

Advances in curative treatment to remove the primary tumor have increased survival of
localized cancers for most solid tumor types, yet cancers that have spread are typically …

Introduction Death due to cancer is mostly associated with therapy ineffectiveness, ie tumor
cells no longer responding to treatment. The underlying dynamics that facilitate this …

Background Tumor resistance to chemotherapy may be present at the beginning of
treatment, develop during treatment, or become apparent on re-treatment of the patient. The …

Most current therapies are directed toward “fighting” cancer by playing against its strengths.
Here, I suggest that alternative strategies that would be directed against cancer evolutionary …

Cancer is an inevitable collateral problem inherent in the evolution of multicellular
organisms, which appeared at the end of the Precambrian. Faced to this constraint, a range …

Few clinical trials incorporate studies of evolutionary cancer biology, despite the frequent
emergence of acquired resistance to anticancer therapies. This problem motivated the first …

The development of resistance to chemotherapy is a critical yet poorly understood
phenomenon driving cancer-related deaths. We recently reported a study that explored the …

At present, cancers are described in both biological and clinical settings with static models
that characterize tumors by the phenotypic and genotypic features observed at a given time …