Our understanding of the role of stem cells in cancer development is evolving quickly. In the
course of tumor expansion, a subpopulation of tumor cells with stem cell-like features has …

Cancer develops resistance to treatments through many mechanisms. Single-cell analyses
reveal the intratumor heterogeneity and dynamic relationships between cancer cell …

The atavism theory postulates that cancer is the reversion to ancestral single-cell behaviors
in cells of multicellular organisms, possibly representing a speciation event. This …

Despite the great progress in our understanding of the molecular basis of human cancer, the
heterogeneity of individual tumors and the evolutionary pressures imposed by therapy have …

The cancer stem cell hypothesis poses that the bulk of differentiated cells are non-
tumorigenic and only a subset of cells with self-renewal capabilities drive tumor initiation …

The evolutionary dynamics of colorectal metastasis and the role of the epigenome in
disease progression remain to be fully determined. We have used multi-region, multi-omic …

Cancer therapy selects for cancer cells resistant to treatment, a process that is fundamentally
evolutionary. To what extent, however, is the evolutionary perspective employed in research …

The remarkable advances in precision medicine and the development of targeted cancer
treatments have generated significant optimism based on the assumption that a better …

A very recent study by Russo et al. published in Science demonstrates that colorectal cancer
(CRC) cells adapt to targeted therapies by downregulating DNA repair at the expense of an …