190 Background: Therapies targeting oncogenic driver mutations have radically altered the
treatment paradigm for mCRC and improved outcomes. New selective inhibitors aim to …

Long-term survivors of metastatic colorectal cancer (mCRC) who experience multiple
recurrences with resectable oligometastatic disease provide an opportunity to explore the …

Our understanding of the role of stem cells in cancer development is evolving quickly. In the
course of tumor expansion, a subpopulation of tumor cells with stem cell-like features has …

Simple Summary Colorectal cancer (CRC) causes a high number (more than 800,000) of
deaths worldwide each year. Better methods for early diagnosis and the development of …

Resistance to therapy is a major impediment in treating cancer. Resistance is generally held
to arise primarily through random genetic mutations and the subsequent expansion of …

Functional lineage tracing to study the clonal evolution of therapy resistance | Nature Reviews
Cancer Skip to main content Thank you for visiting nature.com. You are using a browser version …

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Background Detecting acquired resistance to targeted therapies with liquid biopsy is a
promising, non-invasive strategy to monitor therapeutic efficacy in real time. We explored the …

Introduction. One of the challenges in the management of patients with cancer of the
digestive tract is to prevent relapse. Epigenetic modifications (ie DNA methylation and …