The tumor form of pyruvate kinase M2 has been suggested to promote cellular anabolism by
redirecting the metabolism to cause accumulation of glycolytic intermediates and increasing …

Abstract Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that is expressed in cancer cells.
Its role in tumor metabolism is not definitively established, but investigators have suggested …

One hundred years ago, Otto Heinrich Warburg observed that postmitotic retinal cells are the
highest oxygen-consuming cells in the body. He compared these cells to actively growing …

Pyruvate kinase isozyme type M2 (PKM2), a key glycolytic enzyme, which is involved in ATP
generation and pyruvate production, participates in tumor metabolism, growth, and other …

Photoreceptor death is the root cause of vision loss in many retinal disorders, and there is an
unmet need for neuroprotective modalities to improve photoreceptor survival. The …

The tumor form of pyruvate kinase M2 (PKM2) undergoes tyrosine phosphorylation and
gives rise to the Warburg effect. The Warburg effect defines a pro-oncogenic metabolism …

Purpose: Like cancer cells, photoreceptor cells produce lactate aerobically, requiring lactate
dehydrogenase A (LDH-A). Cancer cells also use glycolytic intermediates for biosynthesis …

Purpose.: Downregulation of the retinal insulin/mTOR pathway in mouse models of retinitis
pigmentosa is linked to cone cell death, which can be delayed by systemic administration of …

Photoreceptor cell death is the ultimate cause of vision loss in many retinal disorders, and
there is an unmet need for neuroprotective modalities to improve photoreceptor survival …

The main therapeutic goal for diabetic retinopathy (DR) is to prevent vision loss in patients
with diabetes mellitus. Identifying the visual complications at a preclinical juncture will offer …