There is increasing evidence that complement may play a role in bone development. Our
previous studies demonstrated that the key complement receptor C5aR was strongly …

Severely injured patients frequently suffer compromised fracture healing because of
systemic post-traumatic inflammation. An important trigger of the posttraumatic immune …

The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune
responses, but also in bone metabolism and fracture healing, being highly expressed on …

There is a tight interaction of the bone and the immune system. However, little is known
about the relevance of the complement system, an important part of innate immunity and a …

The growing field of osteoimmunology seeks to unravel the complex interdependence of the
skeletal and immune systems. Notably, we and others have demonstrated that complement …

The complement system, as part of innate immunity, is activated immediately after trauma in
response to various pathogen-and danger-associated molecular patterns (PAMPs and …

In recent years, evidence has accumulated that the complement system, an integral part of
innate immunity, may be involved in the regulation of bone homeostasis as well as …

Bone remodeling is regulated by a coupling of resorption to subsequent formation; however,
the “coupling factor” and underlying mechanism are not fully understood. Here, we found …

Background: There is evidence that complement components regulate cytokine production
in osteoblastic cells, induce cell migration in mesenchymal stem cells, and play a regulatory …

An integral part of innate immunity is the complement system, a defence system, consisting
of fluid-phase and cell surface-bound proteins. Its role to ensure adequate responses to …