Compelling evidence indicates that radiotherapy (RT) has a systemic inhibitory effect on
nonirradiated lesions (abscopal effect) in addition to the ablation of irradiated tumors …

Radiotherapy has been used for more than a hundred years to cure or locally control tumors.
Regression of tumors outside of the irradiated field was occasionally observed and is known …

Although cancer progression is primarily driven by the expansion of tumor cells, the tumor
microenvironment and anti-tumor immunity also play important roles. Herein, we consider …

Tumor metastasis is a singularly important determinant of survival in most cancers.
Historically, radiation therapy (RT) directed at a primary tumor mass was associated …

Radiotherapy is a pillar of cancer treatment, which has historically been used primarily to
treat localized disease with curative intent. With the increasing role of radiotherapy for …

Radiotherapy (RT) is the primary treatment for cancer. Ionizing radiation from RT induces
tumor damage at the irradiated site, and, although clinically infrequent, may cause …

Radiation therapy (RT) is a cornerstone in oncologic management and is employed in
various curative and palliative scenarios for local-regional control. RT is thought to locally …

Although abscopal tumor regression remains a rare phenomenon, interest in exploiting how
radiation stimulates the immune system to induce systemic abscopal response is increasing …

The concept of utilizing localized radiation therapy to elicit out-of-target tumor responses—
the abscopal effect—was proposed over 50 years ago (1, 2). Over the past decades, the …

Cancer immunotherapy exploits the immune system's ability to differentiate between tumor
target cells and host cells. Except for limited success against a few tumor types, most …