Introdução: A maioria dos estudos experimentais sobre a toxicidade pulmonar induzida por
amiodarona tem sido realizada em ratos machos da linhagem Fischer-344. Objetivos …

Introdução: A maioria dos estudos experimentais sobre a toxicidade pulmonar induzida por
amiodarona tem sido realizada em ratos machos da linhagem Fischer-344. Objetivos …

Patients who receive amiodarone may develop interstitial pulmonary disease. The objective
of the present study was to develop an experimental model of interstitial pulmonary disease …

Amiodarone is a potent antiarrhythmic agent with a number of side-effects, the most serious
being the development of pulmonary toxicity. The purpose of the study was to determine if a …

Administration of single dose (175 mg/kg body wt) of amiodarone dissolved in water through
gavage for 3 weeks damaged the lung and changed the content of lung lavage. Activities of …

A rat model of amiodarone-induced pulmonary toxicity is described. The rats were fed, by
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …

Objective This study was undertaken to investigate the effect of long-term amiodarone
administration and withdrawal on the histological structure of rat lung. In addition, the …

Amiodarone is an antiarrhythmic drug with numerous side effects, the most serious being the
development of pulmonary toxicity. We have previously reported that a single intratra cheal …

In previous studies, we showed that Fischer rats fed 175 mg/kg of amiodarone accumulated
large amounts of drug and metabolite in the lung and developed pulmonary toxicity …

Toinvestigate the relationship between the amount of amiodarone and the major metabolite
N-desethylamiodarone found in the lung with the development of toxicity, Fischer 344 and …