Cancer-promoting effects of microbial dysbiosis

AM Sheflin, AK Whitney, TL Weir - Current oncology reports, 2014 - Springer
Humans depend on our commensal bacteria for nutritive, immune-modulating, and
metabolic contributions to maintenance of health. However, this commensal community …

Cancer and the microbiota

WS Garrett - Science, 2015 - science.org
A host's microbiota may increase, diminish, or have no effect at all on cancer susceptibility.
Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host …

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

SH Wong, J Yu - Nature reviews Gastroenterology & hepatology, 2019 - nature.com
Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …

Gut microbiota and probiotics in colon tumorigenesis

Y Zhu, TM Luo, C Jobin, HA Young - Cancer letters, 2011 - Elsevier
The human gastrointestinal tract harbors a complex and abundant microbial community
reaching as high as 1013–1014 microorganisms in the colon. This endogenous microbiota …

Intestinal bacteria and colorectal cancer: etiology and treatment

MW Dougherty, C Jobin - Gut Microbes, 2023 - Taylor & Francis
The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize
the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible …

Gut microbiota and colorectal cancer

YN Yu, JY Fang - Gastrointestinal tumors, 2015 - karger.com
Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality
worldwide whose incidence has increased rapidly in recent years. There is growing …

Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment

MB Burns, J Lynch, TK Starr, D Knights, R Blekhman - Genome medicine, 2015 - Springer
Background The human gut microbiome is associated with the development of colon cancer,
and recent studies have found changes in the microbiome in cancer patients compared to …

Cancer induces a stress ileopathy depending on β-adrenergic receptors and promoting dysbiosis that contributes to carcinogenesis

S Yonekura, S Terrisse, C Alves Costa Silva, A Lafarge… - Cancer discovery, 2022 - AACR
Gut dysbiosis has been associated with intestinal and extraintestinal malignancies, but
whether and how carcinogenesis drives compositional shifts of the microbiome to its own …

Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures

I Sobhani, E Bergsten, S Couffin… - Proceedings of the …, 2019 - National Acad Sciences
Sporadic colorectal cancer (CRC) is a result of complex interactions between the host and
its environment. Environmental stressors act by causing host cell DNA alterations implicated …

Co-occurrence of driver and passenger bacteria in human colorectal cancer

J Geng, Q Song, X Tang, X Liang, H Fan, H Peng… - Gut pathogens, 2014 - Springer
Background Both genetic and epigenetic alterations have been reported to act as driving
forces of tumorigenesis in colorectal cancer (CRC), but a growing body of evidence …