Introduction Several lines of evidence point to a key role for dynamic epigenetic changes
during brain development, maturation, and learning. DNA methylation (mC) is a stable …

Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Understanding the diversity of human tissues is fundamental to disease and requires linking
genetic information, which is identical in most of an individual's cells, with epigenetic …

Background Alzheimer's disease affects~ 13% of people in the United States 65 years and
older, making it the most common neurodegenerative disorder. Recent work has identified …

Abstract MethBank (http://bigd. big. ac. cn/methbank) is a database that integrates high-
quality DNA methylomes across a variety of species and provides an interactive browser for …

Introduction DNA methylation is a key epigenetic mechanism in brain aging and Alzheimer's
disease (AD). The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation …

Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …

We report a novel resource (m ethylation p rofiles of D NA, or mPod) for human genome-
wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts …

DNA methylation is a critical regulatory mechanism implicated in development, learning,
memory, and disease in the human brain. Here we have elucidated DNA methylation …

Abstract Changes in potential regulatory elements are thought to be key drivers of
phenotypic divergence. However, identifying changes to regulatory elements that underlie …