Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes
RF Pérez, P Santamarina, JR Tejedor… - Journal of translational …, 2019 - Springer
Background Early life is a period of drastic epigenetic remodeling in which the epigenome is
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …
The methylome: approaches for global DNA methylation profiling
S Beck, VK Rakyan - Trends in Genetics, 2008 - cell.com
DNA methylation plays a critical role in genome function both in health and disease. Almost
60 years after the discovery of 5-methyl cytosine and∼ 25 years since the discovery that …
60 years after the discovery of 5-methyl cytosine and∼ 25 years since the discovery that …
Human DNA methylomes at base resolution show widespread epigenomic differences
DNA cytosine methylation is a central epigenetic modification that has essential roles in
cellular processes including genome regulation, development and disease. Here we …
cellular processes including genome regulation, development and disease. Here we …
Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation
Background DNA methylation (DNAm) is a critical regulator of both development and
cellular identity and shows unique patterns in neurons. To better characterize maturational …
cellular identity and shows unique patterns in neurons. To better characterize maturational …
A pan-tissue DNA methylation atlas enables in silico decomposition of human tissue methylomes at cell-type resolution
Bulk-tissue DNA methylomes represent an average over many different cell types,
hampering our understanding of cell-type-specific contributions to disease development. As …
hampering our understanding of cell-type-specific contributions to disease development. As …
Dynamic DNA methylation across diverse human cell lines and tissues
As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …
a complex relationship with gene expression, plays an important role in defining cell types …
Postnatal development-and age-related changes in DNA-methylation patterns in the human genome
P Salpea, VR Russanova, TH Hirai… - Nucleic acids …, 2012 - academic.oup.com
Alterations in DNA methylation have been reported to occur during development and aging;
however, much remains to be learned regarding post-natal and age-associated epigenome …
however, much remains to be learned regarding post-natal and age-associated epigenome …
Distinct DNA methylomes of newborns and centenarians
Human aging cannot be fully understood in terms of the constrained genetic setting.
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex
Background Epigenome-wide association studies (EWAS) based on human brain samples
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …
Genome-scale DNA methylation maps of pluripotent and differentiated cells
DNA methylation is essential for normal development,, and has been implicated in many
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …