[HTML][HTML] A genome-wide study of DNA methylation patterns and gene expression levels in multiple human and chimpanzee tissues
The modification of DNA by methylation is an important epigenetic mechanism that affects
the spatial and temporal regulation of gene expression. Methylation patterns have been …
the spatial and temporal regulation of gene expression. Methylation patterns have been …
[HTML][HTML] DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
KD Siegmund, CM Connor, M Campan, TI Long… - PloS one, 2007 - journals.plos.org
The role of DNA cytosine methylation, an epigenetic regulator of chromatin structure and
function, during normal and pathological brain development and aging remains unclear …
function, during normal and pathological brain development and aging remains unclear …
DNA methylation contributes to natural human variation
DNA methylation patterns are important for establishing cell, tissue, and organism
phenotypes, but little is known about their contribution to natural human variation. To …
phenotypes, but little is known about their contribution to natural human variation. To …
QSER1 protects DNA methylation valleys from de novo methylation
INTRODUCTION DNA methylation is essential to mammalian development, and
dysregulation can cause serious pathological conditions, including immunodeficiency …
dysregulation can cause serious pathological conditions, including immunodeficiency …
[HTML][HTML] Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
K Day, LL Waite, A Thalacker-Mercer, A West… - Genome biology, 2013 - Springer
Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …
tissues, although the mechanisms and specificity of this process are still poorly understood …
Targeted retrieval and analysis of five Neandertal mtDNA genomes
Analysis of Neandertal DNA holds great potential for investigating the population history of
this group of hominins, but progress has been limited due to the rarity of samples and …
this group of hominins, but progress has been limited due to the rarity of samples and …
Dynamic changes in the human methylome during differentiation
DNA methylation is a critical epigenetic regulator in mammalian development. Here, we
present a whole-genome comparative view of DNA methylation using bisulfite sequencing of …
present a whole-genome comparative view of DNA methylation using bisulfite sequencing of …
[HTML][HTML] DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns
Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
[HTML][HTML] Aging effects on DNA methylation modules in human brain and blood tissue
Background Several recent studies reported aging effects on DNA methylation levels of
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …
[HTML][HTML] An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene
A growing number of epigenome-wide association studies have demonstrated a role for
DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral …
DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral …