Background DNA methylation is an epigenetic mark that balances plasticity with stability.
While DNA methylation exhibits tissue specificity, it can also vary with age and potentially …

An outstanding challenge of epigenome-wide association studies (EWASs) performed in
complex tissues is the identification of the specific cell type (s) responsible for the observed …

Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-
suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may …

DNA methylation is a central regulator of genome function, and altered methylation patterns
are indicative of biological aging and mortality. Age‐related cellular, biochemical, and …

DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …

While cytosine methylation has been widely studied in extant populations, relatively few
studies have analyzed methylation in ancient DNA. Most existing studies of epigenetic …

Mammalian development requires cytosine methylation, a heritable epigenetic mark of
cellular memory believed to maintain a cell's unique gene expression pattern. However, it …

DNA methylation constitutes an important epigenetic regulation mechanism in many
eukaryotes, although the extent of DNA methylation in the regulation of gene expression in …

Epigenomics regulates gene expression and is as important as genomics in precision
personal health, as it is heavily influenced by environment and lifestyle. We profiled whole …

DNA methylation is a key epigenetic property that drives gene regulatory programs in
development and disease. Current single-cell methods that produce high quality …