[HTML][HTML] DNA methylation dynamics in aging: how far are we from understanding the mechanisms?
F Ciccarone, S Tagliatesta, P Caiafa… - Mechanisms of ageing …, 2018 - Elsevier
DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …
predicting life expectancy. However, the mechanisms underlying age-related DNA …
[HTML][HTML] Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development
Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …
are frequent events and play major roles regulating gene expression and other …
[HTML][HTML] Universal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method
The genome-wide distribution patterns of the '6th base'5-hydroxymethylcytosine (5hmC) in
many tissues and cells have recently been revealed by hydroxymethylated DNA …
many tissues and cells have recently been revealed by hydroxymethylated DNA …
Resurrecting surviving Neandertal lineages from modern human genomes
Anatomically modern humans overlapped and mated with Neandertals such that non-
African humans inherit~ 1 to 3% of their genomes from Neandertal ancestors. We identified …
African humans inherit~ 1 to 3% of their genomes from Neandertal ancestors. We identified …
Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
A Kozlenkov, P Roussos, A Timashpolsky… - Nucleic acids …, 2014 - academic.oup.com
Abstract We applied Illumina Human Methylation450K array to perform a genomic-scale
single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily …
single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily …
Charting a dynamic DNA methylation landscape of the human genome
DNA methylation is a defining feature of mammalian cellular identity and is essential for
normal development,. Most cell types, except germ cells and pre-implantation embryos …
normal development,. Most cell types, except germ cells and pre-implantation embryos …
[HTML][HTML] Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species
Background Mammalian species exhibit a wide range of lifespans. To date, a robust and
dynamic molecular readout of these lifespan differences has not yet been identified. Recent …
dynamic molecular readout of these lifespan differences has not yet been identified. Recent …
Large-scale methylation domains mark a functional subset of neuronally expressed genes
DI Schroeder, P Lott, I Korf, JM LaSalle - Genome research, 2011 - genome.cshlp.org
DNA methylation is essential for embryonic and neuronal differentiation, but the function of
most genomic DNA methylation marks is poorly understood. Generally the human genome …
most genomic DNA methylation marks is poorly understood. Generally the human genome …
[HTML][HTML] DNA methylation, a hand behind neurodegenerative diseases
H Lu, X Liu, Y Deng, H Qing - Frontiers in aging neuroscience, 2013 - frontiersin.org
Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …