TRPV4 channels: physiological and pathological role in cardiovascular system

PK Randhawa, AS Jaggi - Basic research in cardiology, 2015 - Springer
TRPV4 channels are non-selective cation channels permeable to Ca 2+, Na+, and Mg 2+
ions. Recently, TRPV4 channels have received considerable attention as these channels …

TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells

MH Vos, TR Neelands, HA McDonald… - Journal of …, 2006 - Wiley Online Library
Transient receptor potential channel type V (TRPV) 1 is a non‐selective cation channel that
can be activated by capsaicin, endogenous vanilloids, heat and protons. The human TRPV1 …

Activation and activators of TRPV1 and their pharmaceutical implication

YG Suh, U Oh - Current pharmaceutical design, 2005 - ingentaconnect.com
TRPV1 is a channel expressed highly in small sensory neurons. TRPV1 is a ligand-gated,
cation channel that is activated by heat, acid and capsaicin, a principal ingredient in hot …

Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase

X Jin, N Morsy, J Winston, PJ Pasricha… - … of Physiology-Cell …, 2004 - journals.physiology.org
The capsaicin receptor TRPV1 is a nonselective cation channel that is expressed in sensory
neurons. In this study, we examined the role of the nonreceptor cellular tyrosine kinase c-Src …

[HTML][HTML] A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis

S Xu, B Liu, M Yin, M Koroleva, M Mastrangelo… - Oncotarget, 2016 - ncbi.nlm.nih.gov
TRPV4 ion channel mediates vascular mechanosensitivity and vasodilation. Here, we
sought to explore whether non-mechanical activation of TRPV4 could limit vascular …

Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons

V Lukacs, Y Yudin, GR Hammond… - Journal of …, 2013 - Soc Neuroscience
Transient Receptor Potential Vanilloid 1 (TRPV1) is a polymodal, Ca2+-permeable cation
channel crucial to regulation of nociceptor responsiveness. Sensitization of TRPV1 by G …

Transient receptor potential vanilloid type 4–deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo

DX Zhang, SA Mendoza, AH Bubolz, A Mizuno… - …, 2009 - Am Heart Assoc
Agonist-induced Ca2+ entry is important for the synthesis and release of vasoactive factors
in endothelial cells. The transient receptor potential vanilloid type 4 (TRPV4) channel, a …

Capsaicin, nociception and pain

B Frias, A Merighi - Molecules, 2016 - mdpi.com
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …

Pathophysiological Roles of the TRPV4 Channel in the Heart

S Chaigne, S Barbeau, T Ducret, R Guinamard… - Cells, 2023 - mdpi.com
The transient receptor potential vanilloid 4 (TRPV4) channel is a non-selective cation
channel that is mostly permeable to calcium (Ca2+), which participates in intracellular Ca2+ …

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress

SA Mendoza, J Fang, DD Gutterman… - American Journal …, 2010 - journals.physiology.org
The transient receptor potential vallinoid type 4 (TRPV4) channel has been implicated in the
endothelial shear response and flow-mediated dilation, although the precise functions of this …