TRPV1 ion channels mediate the response to painful heat, extracellular acidosis, and
capsaicin, the pungent extract from plants in the Capsicum family (hot chili …

The capsaicin receptor, TRPV1 (VR1), is a sensory neuron-specific ion channel that serves
as a polymodal detector of pain-producing chemical and physical stimuli. Extracellular Ca2+ …

Src family tyrosine kinases (SFKs) regulate the function of several transient receptor
potential (TRP) family members, yet their role in the regulation of the vanilloid subfamily …

TRPV4 is a non-selective cation channel subunit expressed in a wide variety of tissues. TRP
channels are formed by a tetrameric complex of channel subunits. The available evidence …

Capsaicin and other naturally occurring pungent molecules have been used for centuries as
topical analgesics to treat a variety of painful conditions. However, only within the last 12 …

The capsaicin receptor and transient receptor potential channel TRPV1 senses heat,
protons, and vanilloid agonists in peripheral sensory ganglia. Abundant data have …

Peripheral inflammation leads to ipsilateral and contralateral mechanical hyperalgesia. The
transient receptor potential channel vanilloid type 1 (TRPV1), a nonselective cation channel …

Background: Transient receptor potential (TRP) channels are a superfamily of ion channels
termed after the trp gene in Drosophila that are diverse in structure and control a wide range …

The transient receptor potential vanilloid type 4 (TRPV4) channel, a Ca2+‐permeable
nonselective cation channel, is widely distributed in the circulatory system, particularly in …

Capsaicin, an activator of the transient potential vanilloid receptor type 1 (TRPV1), is a
commonly used pharmacological tool for desensitising sensory nerves. Capsaicin can …