We have generalized the double nucleation mechanism of Ferrone et al.(Ferrone, FA, J.
Hofrichter, H. Sunshine, and WA Eaton. 1980. Biophys. J. 32: 361–377; Ferrone, FA, J …

We have monitored the growth of domains of sickle hemoglobin polymers by using
temporally and spatially resolved light scattering and birefringence measured …

The polymerization kinetics of sickle cell hemoglobin are found to exhibit stochastic
variations when observed in very small volumes (~ 10− 10 cm 3). The distribution of …

A double nucleation mechanism for the polymerization of sickle hemoglobin is described.
The mechanism accounts for all of the major kinetic observations: the appearance of a …

The homogeneous nucleation rate for sickle hemoglobin polymerization has been
measured for concentrations from 3.9 to 4.9 mM and temperatures from 13 degrees C to 35 …

Using experimentally observed processes of linear growth, heterogeneous nucleation, and
polymer bending, with no additional assumptions, we have been able to model the two …

Using a combination of laser photolysis and temperature-jump techniques, the kinetics of
hemoglobin S polymerization have been studied over a wide range of delay times (10− 3 to …

The polymerization of sickle hemoglobin involves the assembly of 14 stranded fibers, which
are found in dense multibranched arrays (Briehl, 1995; White & Heagan, 1970) called …

The measurement of polymer growth is an essential element in characterization of
assembly. We have developed a precise method of measuring the growth of sickle …

Sickle hemoglobin nucleation occurs in solution as a homogeneous process or on existing
polymers in a heterogeneous process. We have developed an analytic formulation to …