Results from preclinical rodent studies during the last 20 years implicated glutamate
neurotransmission in different brain regions in drug self-administration and rodent models of …

There is now compelling evidence that the excitatory amino acid neurotransmitter glutamate
plays a pivotal role in drug addiction and alcoholism. As a result, there has been increasing …

Addiction to drugs of abuse is a disorder that involves dysfunctions in motivational
processes. Both the primary rewarding effects of drugs, as well as the acquired motivational …

Glutamate plays a pivotal role in regulating drug self-administration and drug-seeking
behavior, and the past decade has witnessed a substantial surge of interest in the role of …

Historically, brain catecholamine systems have been the primary focus of studies examining
the neural substrates of drug addiction. In the past two decades, however, a wealth of …

Rationale Group II metabotropic glutamate receptors (mGluR2 and mGluR3) have been
suggested to play an important role in mediation of drug-reinforced behaviors, as well as in …

Drug addiction is characterized by drug-induced positive affect, followed by withdrawal-
associated negative affect. Such drug-induced positive and negative affective states provide …

Drug abuse and dependence on licit and illicit drugs continues to be a significant public
health problem in the United States that leads to serious behavioral problems and health …

Drug addiction is characterized by maladaptive decision-making and dysfunctional brain
circuitry regulating motivated behaviors, resulting in loss of the behavioral flexibility needed …

The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors
that participate in the modulation of synaptic transmission and neuronal excitability …