KCTD10 regulates brain development by destabilizing brain disorder–associated protein KCTD13
J Cheng, Z Wang, M Tang, W Zhang… - Proceedings of the …, 2024 - National Acad Sciences
KCTD10 belongs to the KCTD (potassiumchannel tetramerization domain) family, many
members of which are associated with neuropsychiatric disorders. However, the biological …
members of which are associated with neuropsychiatric disorders. However, the biological …
Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects
JH Liang, J Alevy, V Akhanov, R Seo… - Disease Models & …, 2022 - journals.biologists.com
Mutations in the potassium channel tetramerization domain-containing 7 (KCTD7) gene are
associated with a severe neurodegenerative phenotype characterized by childhood onset of …
associated with a severe neurodegenerative phenotype characterized by childhood onset of …
[HTML][HTML] KCTD5 Forms Hetero-Oligomeric Complexes with Various Members of the KCTD Protein Family
Y Liao, DC Sloan, JH Widjaja, BS Muntean - International journal of …, 2023 - mdpi.com
Potassium Channel Tetramerization Domain 5 (KCTD5) regulates diverse aspects of
physiology, ranging from neuronal signaling to colorectal cancer. A key feature of KCTD5 is …
physiology, ranging from neuronal signaling to colorectal cancer. A key feature of KCTD5 is …
Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport
MN Moen, R Fjær, EH Hamdani, JK Laerdahl… - Brain, 2016 - academic.oup.com
Progressive myoclonus epilepsy is a heterogeneous group of disorders characterized by
myoclonic and tonic-clonic seizures, ataxia and cognitive decline. We here present two …
myoclonic and tonic-clonic seizures, ataxia and cognitive decline. We here present two …
[HTML][HTML] The oncosuppressive properties of KCTD1: its role in cell growth and mobility
G Smaldone, G Pecoraro, K Pane, M Franzese… - Biology, 2023 - mdpi.com
Simple Summary Members of the KCTD protein family play major roles in numerous
physiopathological functions. Although they are traditionally considered to be involved in …
physiopathological functions. Although they are traditionally considered to be involved in …
KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders
X Teng, A Aouacheria, L Lionnard… - CNS neuroscience & …, 2019 - Wiley Online Library
The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not
known. In contrast, mechanistic understanding of other brain disorders including …
known. In contrast, mechanistic understanding of other brain disorders including …
Protein partners of KCTD proteins provide insights about their functional roles in cell differentiation and vertebrate development
The KCTD family includes tetramerization (T1) domain containing proteins with diverse
biological effects. We identified a novel member of the KCTD family, BTBD10. A …
biological effects. We identified a novel member of the KCTD family, BTBD10. A …
[HTML][HTML] KCTD15 deregulation is associated with alterations of the NF-κB signaling in both pathological and physiological model systems
G Smaldone, L Coppola, K Pane, M Franzese… - Scientific Reports, 2021 - nature.com
Like other KCTD proteins, KCTD15 is involved in important albeit distinct biological
processes as cancer, neural crest formation, and obesity. Here, we characterized the role of …
processes as cancer, neural crest formation, and obesity. Here, we characterized the role of …
Compound heterozygous KCTD7 variants in progressive myoclonus epilepsy
EA Burke, M Sturgeon, DB Zastrow… - Journal of …, 2021 - Taylor & Francis
KCTD7 is a member of the potassium channel tetramerization domain-containing protein
family and has been associated with progressive myoclonic epilepsy (PME), characterized …
family and has been associated with progressive myoclonic epilepsy (PME), characterized …
Kctd13 deletion reduces synaptic transmission via increased RhoA
Copy-number variants of chromosome 16 region 16p11. 2 are linked to neuropsychiatric
disorders,,,,, and are among the most prevalent in autism spectrum disorders,,. Of many …
disorders,,,,, and are among the most prevalent in autism spectrum disorders,,. Of many …