In this study, we investigated the molecular mechanisms underlying the ATP analogue
adenosine-5′-O-(3-thio) triphosphate–induced nucleocytoplasmic shuttling of the mRNA …

The cyclooxygenase-2 (COX-2) gene encodes the inducible prostaglandin synthase
enzyme implicated in inflammation, cell growth, and tumorigenesis. Regulation of the COX-2 …

The mRNA stabilizing factor HuR is involved in the posttranscriptional regulation of many
genes, including that coding for cyclooxygenase 2 (COX-2). Employing RNA interference …

Cyclooxygenase-2 (COX-2) expression is normally tightly regulated. However, constitutive
overexpression plays a key role in colon carcinogenesis. To understand the molecular …

Stabilization of mRNA by the ubiquitous RNA binding protein human antigen R (HuR), a
member of the embryonic lethal abnormal vision (ELAV) protein family, requires canonical …

COX-2 (cyclo-oxygenase-2) mRNA is degraded rapidly in resting cells, but is stabilized by
the mitogen-activated protein kinase p38 signalling pathway in response to pro …

A tetracycline-regulated reporter system was used to investigate the regulation of
cyclooxygenase 2 (Cox-2) mRNA stability by the mitogen-activated protein kinase (MAPK) …

Background & Aims: Cyclooxygenase-2 (COX-2) expression is regulated at the levels of
messenger RNA (mRNA) stability and translation by AU-rich elements (ARE) located in its …

The activation of cytosolic phospholipase A 2 α (cPLA 2 α) plays an important role in
initiating the inflammatory response. The regulation of cPLA 2 α mRNA turnover has been …

A predominantly nuclear RNA-binding protein, HuR translocates to the cytoplasm in
response to stress and proliferative signals, where it stabilizes or modulates the translation …