sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
A Kaur, MR Webster, K Marchbank, R Behera, A Ndoye… - Nature, 2016 - nature.com
Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer
prognosis than young. This may be due to accumulated cellular damage, decreases in …
prognosis than young. This may be due to accumulated cellular damage, decreases in …
Senescence-associated reprogramming promotes cancer stemness
M Milanovic, DNY Fan, D Belenki, JHM Däbritz, Z Zhao… - Nature, 2018 - nature.com
Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …
Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination
M Montagner, R Bhome, S Hooper, P Chakravarty… - Nature Cell …, 2020 - nature.com
The process of metastasis is complex. In breast cancer, there are frequently long time
intervals between cells leaving the primary tumour and growth of overt metastases …
intervals between cells leaving the primary tumour and growth of overt metastases …
Stromal changes in the aged lung induce an emergence from melanoma dormancy
Disseminated cancer cells from primary tumours can seed in distal tissues, but may take
several years to form overt metastases, a phenomenon that is termed tumour dormancy …
several years to form overt metastases, a phenomenon that is termed tumour dormancy …
Reversible and adaptive resistance to BRAF (V600E) inhibition in melanoma
Abstract Treatment of BRAF (V600E) mutant melanoma by small molecule drugs that target
the BRAF or MEK kinases can be effective, but resistance develops invariably,. In contrast …
the BRAF or MEK kinases can be effective, but resistance develops invariably,. In contrast …
Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer
D Di Mitri, A Toso, JJ Chen, M Sarti, S Pinton, TR Jost… - Nature, 2014 - nature.com
Aberrant activation of oncogenes or loss of tumour suppressor genes opposes malignant
transformation by triggering a stable arrest in cell growth, which is termed cellular …
transformation by triggering a stable arrest in cell growth, which is termed cellular …
Senescence rewires microenvironment sensing to facilitate antitumor immunity
Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that,
in some instances, stimulates the immune clearance of senescent cells. Using an immune …
in some instances, stimulates the immune clearance of senescent cells. Using an immune …
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
Cellular senescence has been recently shown to have an important role in opposing tumour
initiation and promotion. Senescence induced by oncogenes or by loss of tumour …
initiation and promotion. Senescence induced by oncogenes or by loss of tumour …
Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis
MD Wellenstein, SB Coffelt, DEM Duits… - Nature, 2019 - nature.com
Cancer-associated systemic inflammation is strongly linked to poor disease outcome in
patients with cancer,. For most human epithelial tumour types, high systemic neutrophil-to …
patients with cancer,. For most human epithelial tumour types, high systemic neutrophil-to …
W nt5 A promotes an adaptive, senescent‐like stress response, while continuing to drive invasion in melanoma cells
MR Webster, M Xu, KA Kinzler, A Kaur… - Pigment cell & …, 2015 - Wiley Online Library
We have previously shown that W nt5 A drives invasion in melanoma. We have also shown
that W nt5 A promotes resistance to therapy designed to target the BRAF V600E mutation in …
that W nt5 A promotes resistance to therapy designed to target the BRAF V600E mutation in …