Background Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD
mouse model of Alzheimer's disease (AD) reduces brain neuroinflammation and …

We previously reported that deficiency of membrane-type five matrix metalloproteinase (MT5-
MMP) prevents amyloid pathology in the cortex and hippocampus of 5xFAD mice, and …

Abstract Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly
expressed in the nervous system with emerging roles in brain pathophysiology. The …

Matrix metalloproteinases (MMPs) are pleiotropic endopeptidases involved in a variety of
neurodegenerative/neuroinflammatory processes through their interactions with a large …

The study for the pathophysiology study of Alzheimer's disease (AD) has been hampered by
lack animal models that recapitulate the major AD pathologies, including extracellular β …

During aging the brain displays an increased proinflammatory status, which is associated
with the pathogenesis of aging-related diseases such as Alzheimer's and Parkinson …

Background Neuroinflammation is an important feature of Alzheimer's disease (AD).
Understanding which aspects of the immune system are important in AD may lead to new …

We have recently identified in a transgenic mouse model of Alzheimer's disease (AD)
membrane-type 5-MMP (MT5-MMP) as a new player in Alzheimer's pathogenesis, which …

Accumulation of amyloid-β (Αβ) peptide is believed to play a central role in the pathogenesis
of Alzheimer's disease (AD). Lowering Aβ levels in the brain may thus improve synaptic and …

Background Abnormal accumulation of amyloid β-protein (Aβ) in the brain plays an
important role in the pathogenesis\of Alzheimer's disease (AD). Aβ monomers assemble into …