E vidence has consistently indicated that activation of sphingomyelinases and/or ceramide
synthases and the resulting accumulation of ceramide mediate cellular responses to …

The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

Sphingomyelin is an abundant component of eukaryotic membranes. A specific enzyme,
sphingomyelinase can convert this lipid to ceramide, a central second messenger in cellular …

Farber disease (FD) is a severe inherited disorder of lipid metabolism characterized by
deficient lysosomal acid ceramidase (ACDase) activity, resulting in ceramide accumulation …

A uniquely sensitive method for ceramide domain detection allowed us to study in detail
cholesterol-ceramide interactions in lipid bilayers with low (physiological) ceramide …

Sphingolipid molecules act as bioactive lipid messengers and exert their actions on the
regulation of various cellular signaling pathways. Sphingolipids play essential roles in …

Sphingolipids (SLs) have been considered for many years as predominant building blocks
of biological membranes with key structural functions and little relevance in cellular …

There is strong evidence indicating a role for ceramide as a second messenger in processes
such as apoptosis, cell growth and differentiation, and cellular responses to stress …

Sphingolipids are bioactive lipids found in cell membranes that exert a critical role in signal
transduction. In recent years, it has become apparent that sphingolipids participate in …

It was reported previously that ceramide-1-phosphate (Cer-1-P) is mitogenic for fibroblasts
(Gómez-Muñoz, A., PA Duffy, A. Martin, L. O'Brien, HS. Byun, R. Bittman, and DN Brindley …