Antigen-presenting cells (APCs) can induce T cell activation as well as T cell tolerance. The
molecular mechanisms by which APCs regulate this critical decision of the immune system …

Cytokine signals are known to contribute to CD8+ memory T cell homeostasis, but an exact
understanding of the mechanism (s) has remained elusive. We have now investigated the …

The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …

Type 1 interferons (IFNs) are induced in vivo, administered therapeutically, and potential
targets for amelioration of autoimmune diseases. The cytokines mediate profound …

Using transgenic mice that express a constitutively active version of STAT5b, we
demonstrate that STAT5 plays a key role in governing B cell development and T cell …

Maintaining T cell homeostasis is critical for normal immune response. Three sequential
signals activate T cells, with signal 3 delivered by multiple cytokines that regulate cell …

Abstract A population of CD25+ CD4+ regulatory T cells (T regs) functions to maintain
immunological self tolerance by inhibiting autoreactive T cell responses. CD25+ CD4+ T …

Myeloid immune cells, such as dendritic cells, monocytes, and macrophages, play a central
role in the generation of immune responses and thus are often either disabled or even …

The presence of polyfunctional CD4+ T cells is often associated with favorable antitumor
immunity. We report here that persistent activation of signal transducer and activator of …

The signal transducer and activator of transcription (STAT) proteins are important mediators
for the integration of extrinsic signals provided by cytokines and hormones and thereby …