Sarcopenia is of important clinical relevance for loss of independence in older adults. The
prevalence of obesity in combination with sarcopenia ('sarcopenic-obesity') is increasing at …

Background. An excessive amount of adipose tissue may contribute to sarcopenia and may
be one mechanism underlying accelerated loss of muscle mass and strength with aging. We …

Background Increased lipid accumulation in skeletal muscle has been linked to insulin
resistance, impaired muscle performance, and impaired physical function. It is unclear …

Skeletal muscle (SM) is a large and physiologically important compartment. Adipose tissue
is found interspersed between and within SM groups and is referred to as intermuscular …

Skeletal muscle and bone share common embryological origins from mesodermal cell
populations and also display common growth trajectories early in life. Moreover, muscle and …

Skeletal muscle is integral to the metabolism and utilisation of macronutrients; however,
substantial muscle loss and morphological changes occur with ageing. These are …

Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …

Obesity and type 2 diabetes account for a considerable proportion of the global burden of
age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and …

Sarcopenic obesity is becoming a global health concern, owing to the rising older
population, causing cardiometabolic morbidity and mortality. Loss of muscle exceeding …

Background: Adipose tissue (AT) content of the thigh is generally not considered to be
associated with insulin resistance (IR), but it is unclear whether the distribution of AT in the …