Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory
proteins, referred to as myokines, mediate interactions between skeletal muscle mass and …

Sarcopenia is likely a multifactorial condition that impairs physical function and predisposes
to disability. It may be prevented or treated with lifestyle interventions and pharmacological …

Sarcopenia due to loss of skeletal muscle mass and strength leads to physical inactivity and
decreased quality of life. The number of individuals with sarcopenia is rapidly increasing as …

Worldwide estimates predict 2 billion people will be aged over 65 years by 2050. A major
current challenge is maintaining mobility and quality of life into old age. Impaired mobility is …

Skeletal muscle (SM) plays a central role in many biological functions, such as movement
and metabolism, and alterations in SM mass and composition can have a marked influence …

Context: The accumulation of intramyocellular lipids (IMCLs) and mitochondrial dysfunction
in skeletal muscle have been associated with insulin resistance in obesity. Endurance …

The loss of skeletal muscle mass is observed in many pathophysiological conditions,
including aging and obesity. The loss of muscle mass and function with aging is defined as …

Skeletal muscle is a major organ of insulin-induced glucose metabolism. In addition, loss of
muscle mass is closely linked to insulin resistance (IR) and metabolic syndrome (Met-S) …

Context: Aging is associated with insulin resistance and unfavorable changes in body
composition including increased fat accumulation, particularly in visceral and ectopic …

Abstract In the United Kingdom (UK), it is projected that by 2035 people aged> 65 years will
make up 23% of the population, with those aged> 85 years accounting for 5% of the total …