Rosuvastatin calcium and pravastatin sodium regulate the antioxidant system in zebrafish liver by inhibiting the PI3K/Nrf2/ARE signaling pathway

X WANG, Q MU, X LI, J SHI, R LI, YE ZHAO, C DING - 2024 - researchsquare.com
Rosuvastatin calcium (ROV) and pravastatin sodium (PRA) are commonly used drugs for the
treatment and prevention of cardiovascular diseases, but as a result, they have been …

Simvastatin affects Nrf2/MAPK signaling pathway and hepatic histological structure change in Gambusia affinis

S Bao, J Lin, M Xie, C Wang, X Nie - Chemosphere, 2021 - Elsevier
Simvastatin (SV) is a typical lipid-lowering agent detected widely in waters, so its latent toxic
effects to fish are deserved of concern. The purposes of this study aim at revealing the …

Atorvastatin causes oxidative stress and alteration of lipid metabolism in estuarine goby Mugilogobius abei

Y Wang, C Wang, M Xie, T Tang, Z Wang, X Nie - Environmental Pollution, 2021 - Elsevier
The potential effects of the environmental residues of Atorvastatin (ATV) as a widely used
antilipemic agent on aquatic organisms deserve more investigations because of its high …

[HTML][HTML] Inflammatory stress sensitizes the liver to atorvastatin-induced injury in ApoE-/-mice

W Wu, L Zhao, P Yang, W Zhou, B Li, JF Moorhead… - PLoS …, 2016 - journals.plos.org
Statins, which are revolutionized cholesterol-lowing agents, have been reported to have
unfavorable effects on the liver. Inflammatory stress is a susceptibility factor for drug-induced …

[HTML][HTML] Resveratrol ameliorates oxidative stress, inflammatory response and lipid metabolism in common carp (Cyprinus carpio) fed with high-fat diet

D Wu, J Li, Z Fan, L Wang, X Zheng - Frontiers in Immunology, 2022 - frontiersin.org
High-fat diet is regarded as crucial inducers of oxidative stress, inflammation, and metabolic
imbalance. In order to investigate the ameliorative potential of resveratrol against the …

Hepatotoxicity induced by PPⅥ and PPⅦ in zebrafish were related to the Cholesterol disorder

Z Li, Y Tang, Z Liu, Q Fan, M Chen, Z Lin, C Zhao, R Lin - Phytomedicine, 2022 - Elsevier
Abstract Background PPⅥ 2 and PPⅦ 3 were a group of Pennogenin compounds extracted
from the Paris polyphylla and caused hepatotoxicity in human, while the potential underlying …

[HTML][HTML] Kaempferol-3-O-Glucuronide ameliorates non-alcoholic steatohepatitis in high-cholesterol-diet-induced larval zebrafish and HepG2 cell models via regulating …

Y Deng, J Ma, X Weng, Y Wang, M Li, T Yang, Z Dou… - Life, 2021 - mdpi.com
NAFLD (non-alcoholic fatty liver disease) is one of the most prominent liver diseases in the
world. As a metabolic-related disease, the development of NAFLD is closely associated with …

Tetracycline antibiotics as PI3K inhibitors in the Nrf2-mediated regulation of antioxidative stress in zebrafish larvae

X Yu, Y Wu, M Deng, Y Liu, S Wang, X He… - Chemosphere, 2019 - Elsevier
Scientific concern about veterinary antibiotics (VAs) residues in the aquatic environment has
increased in recent years. However, little is known about the underlying molecular …

Hypoxia aggravates the burden of yellowstripe goby (Mugilogobius chulae) under atorvastatin exposure

Y Wang, T Tang, J Ren, Y Zhao, Y Hou, X Nie - Aquatic Toxicology, 2023 - Elsevier
In the present study, an estuarine benthic fish, Mugilogobius chulae (M. chulae), was
exposed to hypoxia, atorvastatin (ATV), a highly used and widely detected lipid-lowering …

Effects of triclosan on the RedoximiRs/Sirtuin/Nrf2/ARE signaling pathway in mosquitofish (Gambusia affinis)

S Bao, C He, P Ku, M Xie, J Lin, S Lu, X Nie - Aquatic Toxicology, 2021 - Elsevier
Triclosan (TCS) has been widely used in daily life for its broad-spectrum antibacterial
property and subsequently detected frequently in aquatic waterborne. Environmental …