Iron plays an essential role in cellular metabolism and biological processes. However, due
to its intrinsic redox activity, free iron is a potentially toxic molecule in cellular biochemistry …

Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Iron homeostasis is primarily maintained through regulation of its transport. This review
summarizes recent discoveries in the field of iron transport that have shed light on the …

Iron is an essential element for metabolic processes intrinsic to life, and yet the properties
that make iron a necessity also make it potentially deleterious. To avoid harm, iron …

Iron is a crucial factor for life. However, it also has the potential to cause the formation of
noxious free radicals. These double-edged sword characteristics demand a tight regulation …

All eukaryotic organisms require iron to function. Malfunctions within iron homeostasis have
a range of physiological consequences, and can lead to the development of pathological …

Iron is essential for life. Its coordinated distribution between intracellular compartments and
the adaptation of iron uptake to intracellular demands are central for a balanced iron …

Eukaryotic cells contain hundreds of proteins that require iron cofactors for activity. These
iron enzymes are located in essentially every subcellular compartment; thus, iron cofactors …

Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory
mechanisms have evolved to maintain iron homeostasis within cells and between different …