The regulated trafficking of iron through ferritin is important for maintaining a consistent flow
of iron to mitochondria without releasing potentially damaging redox-active species in the …

Cells maintain organellar pools of “labile iron”(LI), despite its propensity for catalyzing the
formation of reactive oxygen species. These pools are identifiable by iron-chelating probes …

Iron is an essential trace element in the human body, but excess iron is toxic as it contributes
to oxidative damage. To keep iron concentration within the optimal physiologic range, iron …

In the present study we analysed the mechanism of intracellular routing of iron acquired by
erythroid cells via receptor-mediated endocytosis of Tf-Fe [Tf (transferrin)-iron]. Using real …

The regulation of iron metabolism in biological systems centers on providing adequate iron
for cellular function while limiting iron toxicity. Because mammals cannot excrete iron …

Iron is an essential nutrient required for a variety of biochemical processes. It is a vital
component of the heme in hemoglobin, myoglobin, and cytochromes and is also an …

Iron is essential for life, but is toxic in excess. Nearly all organisms have therefore developed
regulated mechanisms for efficient transport of iron into cells. This paper reviews the current …

Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron
cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc …

Iron serves essential functions in both prokaryotes and eukaryotes, and cells have highly
specialized mechanisms for acquiring and handling this metal. The primary mechanism by …

The understanding of iron metabolism at the molecular level has been enormously
expanded in recent years by new findings about the functioning of transferrin, the transferrin …