Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS
RR Voskuhl, RS Peterson, B Song, Y Ao… - Journal of …, 2009 - Soc Neuroscience
Factors that regulate leukocyte entry and spread through CNS parenchyma during different
types of CNS insults are incompletely understood. Reactive astrocytes have been implicated …
types of CNS insults are incompletely understood. Reactive astrocytes have been implicated …
Astrocyte barriers to neurotoxic inflammation
MV Sofroniew - Nature Reviews Neuroscience, 2015 - nature.com
Astrocytes form borders (glia limitans) that separate neural from non-neural tissue along
perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function …
perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function …
Protective functions of reactive astrocytes following central nervous system insult
M Linnerbauer, V Rothhammer - Frontiers in immunology, 2020 - frontiersin.org
Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …
The role of astrocytes in multiple sclerosis
The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS)
lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes …
lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes …
Astrocytes: key regulators of neuroinflammation
E Colombo, C Farina - Trends in immunology, 2016 - cell.com
Astrocytes are crucial regulators of innate and adaptive immune responses in the injured
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …
Astrocyte regulation of CNS inflammation and remyelination
KI Claycomb, KM Johnson, PN Winokur, AV Sacino… - Brain sciences, 2013 - mdpi.com
Astrocytes regulate fundamentally important functions to maintain central nervous system
(CNS) homeostasis. Altered astrocytic function is now recognized as a primary contributing …
(CNS) homeostasis. Altered astrocytic function is now recognized as a primary contributing …
Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing …
R Brambilla, PD Morton, JJ Ashbaugh, S Karmally… - Glia, 2014 - Wiley Online Library
Astrocytes respond to insult with a process of cellular activation known as reactive
astrogliosis. One of the key signals regulating this phenomenon is the transcription factor …
astrogliosis. One of the key signals regulating this phenomenon is the transcription factor …
Astrocyte‐T cell crosstalk regulates region‐specific neuroinflammation
JL Williams, S Manivasagam, BC Smith, J Sim… - Glia, 2020 - Wiley Online Library
During multiple sclerosis (MS), an inflammatory and neurodegenerative disease of the
central nervous system (CNS), symptoms, and outcomes are determined by the location of …
central nervous system (CNS), symptoms, and outcomes are determined by the location of …
Astrocyte-immune cell interactions in physiology and pathology
Astrocytes play both physiological and pathological roles in maintaining central nervous
system (CNS) function. Here, we review the varied functions of astrocytes and how these …
system (CNS) function. Here, we review the varied functions of astrocytes and how these …
Innate response to focal necrotic injury inside the blood-brain barrier
We have studied the initial innate immune response to focal necrotic injury on different sides
of the mouse blood-brain barrier by two-photon intravital microscopy. Transgenic mice in …
of the mouse blood-brain barrier by two-photon intravital microscopy. Transgenic mice in …